Impact of sex on the clinicopathological characteristics and prognosis of papillary thyroid cancer

Impact of sex on the clinicopathological characteristics and prognosis of papillary thyroid cancer

Can J Surg 2016;59(4):287-88 | PDF

Ekua Yorke, MD; Adrienne Melck, MD; Sam M. Wiseman, MD

Summary

Papillary thyroid cancer (PTC) is the most common endocrine malignancy. Observed clinical and pathological differences between the sexes of PTC patients have been reported. There is currently no consensus regarding the impact of sex on PTC prognostication. We studied 566 PTC patients and observed that there was a higher PTC incidence in women, that PTC diagnosis was more challenging in women, and that men tended to present with larger cancers. However, once PTC is diagnosed, both sexes have a similar cancer prognosis, as evaluated using the MACIS (Metastasis, Age, Completeness of Resection, Invasion, Size) score. Our observations suggest that research efforts should be especially directed at improving the diagnostic yield of preoperative fine needle aspiration biopsy in women who present with nodular thyroid disease.


Accepted for publication Apr. 6, 2016

Affiliations: From the Department of Surgery, St. Paul’s Hospital and the University of British Columbia, Vancouver, B.C.

Competing interests: None declared.

Contributors: All authors contributed substantially to the conception, writing and revision of this article and approved the final version for publication.

DOI: 10.1503/cjs.003816

Correspondence to: S.M. Wiseman, Department of Surgery, St. Paul’s Hospital and University of, British Columbia, Rm C303, Burrard Building, 1081 Burrard St., Vancouver, BC, V6Z 1Y6; smwiseman@providencehealth.bc.ca