Is obesity associated with advanced stage or grade of colon cancer?

Is obesity associated with advanced stage or grade of colon cancer?

Can J Surg 2015;58(2):140-142 | PDF

Katerina Neumann, MSc, MD; Salaheddin M. Mahmud, MD; Andrew McKay, MD, MSc; Jason Park, MD, MEd; Jennifer Metcalfe, MD; David J. Hochman, MD

Summary

Population-based studies from Europe have suggested that obesity is associated with more advanced stage colorectal cancer on presentation. Obesity is an even more prevalent issue in North America, but comparable data on associations with cancer are lacking. We reviewed the cases of 672 patients with colon cancer diagnosed between 2004 and 2008 in the province of Manitoba who underwent surgical resection at a Winnipeg Regional Health Authority– affiliated hospital. We tested if obesity was associated with more advanced cancer stage or grade. On multivariate analysis, after adjusting for age, sex, tumour location and socioeconomic status, we were unable to show any significant associations between body mass index of 30 or more and advanced stage or grade cancer on presentation. The reasons for the lack of association are likely multifactorial, including the pathophysiology of the disease and process factors, such as screening habits and colonoscopic diagnostic success rates in obese patients.


This work was presented in poster format at the Canadian Surgical Forum in Calgary, Alta., in September 2012, and at the American Society of Colon and Rectal Surgeons meeting in Phoenix, AZ, in April 2013.

Accepted for publication Sept. 10, 2014

Affiliations: From the Department of Surgery, (Neumann, McKay, Park, Metcalfe, Hochman) and Department of Community Health Sciences (Mahmud), University of Manitoba, Winnipeg, Man.; and Cancer Care Manitoba, Winnipeg, Man. (Mahmud, McKay, Park, Hochman).

Competing interests: None declared.

Contributors: All authors contributed substantially to writing and/or revising and to the conception and design of the manuscript and approved the final version submitted for publication.

DOI: 10.1503/cjs.004414

Correspondence to: K. Neumann, St. Boniface Hospital, Z3048-409 Tache Ave., Winnipeg, MB, R2H 2A6; katerina_neumann@yahoo.ca