Background Recombinant factor VIIa (rFVIIa) is licensed for use in patients with haemophilia
and inhibitory allo‐antibodies. It is also increasingly being used for off‐license indications to …

Methods and results We surveyed 108 clinical students (90% response rate) who were
about one year away from completing medical school at the University of Toronto. We asked …

Cryoprecipitate is a diverse product containing factor VIII, von Willebrand factor, fibrinogen,
fibronectin, factor XIII, and platelet microparticles. The role of this complex product in the …

Oral factor Xa inhibitors are increasingly used for anticoagulation, but there is no approved
reversal agent. Prothrombin complex concentrate (PCC) for the management of Xa-inhibitor–…

Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare complication of blood
transfusion. The clinicolaboratory features of TA-GVHD and the relative contributions of …

Fresh frozen plasma (FFP) is indicated for the management of massive bleedings. Recent
audits suggest physician knowledge of FFP is inadequate and half of the FFP transfused in …

Background: Hemorrhage coupled with coagulopathy remains the leading cause of
preventable in-hospital deaths among trauma patients. Use of a transfusion protocol with a …

OBJECTIVE. In the absence of scientific evidence, current neonatal platelet transfusion
practices are based on physicians' preferences, expert advice, or consensus-driven …

Importance Red blood cell transfusion is a common medical intervention with benefits and
harms. Objective To provide recommendations for use of red blood cell transfusion in adults …

Transfusion-associated circulatory overload (TACO) is a common yet underrecognized and
underreported complication of transfusion associated with significant morbidity and mortality. …