We integrated clinical, genomic, and transcriptomic data from 224 primaries and 95 metastases
from 289 patients to characterize progression of pancreatic ductal adenocarcinoma (…

Background. Sequential pancreatic islet transplantation via the portal vein has led to insulin
independence in patients with type 1 diabetes. Complications associated with the injection …

Importance Recent data have suggested that disease biology and outcome of colon cancer
may differ between right-sided and left-sided tumors. However, the literature on the …

With recent advances in methods of islet isolation and the introduction of more potent and
less diabetogenic immunosuppressive therapies, islet transplantation has progressed from …

The use of newer chemotherapeutic agents before resection of colorectal cancer liver metastases
has been linked with parenchymal liver injury, in particular preoperative irinotecan and …

Costimulation blockade is a promising strategy for preventing allograft rejection and
inducing tolerance. Using a fully allogeneic mouse model, we tested the effectiveness of the …

Islet transplantation offers patients with type 1 diabetes mellitus freedom from long-term insulin
therapy and a degree of metabolic control that is far superior to injected insulin. The hope …

Importance Surgical resection is standard treatment for patients with colorectal cancer (CRC)
liver metastases (LM). Limited data describe practice and outcomes among elderly patients…

Objective A fundamental aspect of surgical planning in liver resections is the identification of
key vessel tributaries to preserve healthy liver tissue while fully resecting the tumor(s). …

The ultimate goal of islet transplantation is to completely correct the diabetic state from an
unlimited donor source, without the need for chronic immunosuppressive drug therapy. …