Purified islet allografts have largely failed to maintain long-term glucose homeostasis in
human recipients, and the reasons for this are unclear. It is noteworthy, however, that islet …

OBJECTIVE Proinflammatory cytokines are cytotoxic to β-cells and have been implicated in
the pathogenesis of type 1 diabetes and islet graft failure. The importance of the intrinsic …

Background: Islet isolation exposes the islet to a variety of cellular stresses and disrupts the
cell-matrix relationship—events known to be associated with apoptosis. The purpose of this …

γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-cells.
However, in humans it is unknown whether it can increase β-cell mass and improve …

The stresses encountered during islet isolation and culture may have deleterious effects on
beta-cell physiology. However, the biological response of human islet cells to isolation …

Background Clostridium difficile-associated diarrhea (CDAD) is an increasingly important
diagnosis in solid organ transplant recipients, with rising incidence and mortality. We describe …

Background We recently found that γ-aminobutyric acid (GABA) protects mouse islet β cells.
It prevented autoimmune type 1 diabetes in mice, induced islet β-cell regeneration, and …

The reasons for the failure of clinical islet transplantation remain obscure. Islet isolation,
however, exposes the islet to variety of cellular stresses, including disruption of the cell-matrix …

Type 1 diabetes is due to destruction of pancreatic β-cells. Lysine deacetylase inhibitors (KDACi)
protect β-cells from inflammatory destruction in vitro and are promising …

BACKGROUND: Delirium is common in intensive care unit patients and is associated with
worse outcome.OBJECTIVE: To identify early risk factors for delirium in patients admitted to …