Increased pulmonary microvessel pressure experienced in left heart failure, head trauma, or
high altitude can lead to endothelial barrier disruption referred to as capillary “stress failure” …

α-Synuclein (a-Syn), a protein implicated in Parkinson disease, contributes significantly to
dopamine metabolism. a-Syn binding inhibits the activity of tyrosine hydroxylase (TH), the rate-…

Tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis, is frequently
used as a marker of dopaminergic neuronal loss in animal models of Parkinson's disease (…

Tumor necrosis factor-alpha (TNF-α) specific antibodies (anti-TNF-α Ab) have been shown
to be potent TNF inhibitors and effective therapeutics for a range of inflammatory diseases. …

Biomaterials capable of neutralizing specific cytokines could form the basis for treating a broad
range of conditions characterized by intense, local inflammation. Severe burns, spanning …

In this study, we explored whether topical application of antibodies targeting tumor necrosis
factor‐α ( TNF ‐α) or interleukin‐6 ( IL ‐6) conjugated to hyaluronic acid ( HA ) could reduce …

Disruption of the barrier function of skin increases transepidermal water loss and up-regulates
inflammatory pathways in the epidermis. Consequently, sustained expression of …

Autoinflammatory skin diseases are characterized by a disequilibrium of cytokines in the
local skin microenvironment, suggesting that local delivery of therapeutics, including …

Hypertrophic scar is a major clinical outcome of deep‐partial thickness to full thickness thermal
burn injury. Appropriate animal models are a limitation to burn research due to the lack of…

Detergents such as sodium dodecyl sulfate (SDS) are commonly used to extract cells from
tissues in a process called “decellularization”. Residual SDS is difficult to completely remove …