R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

Telomeres, the physical ends of eukaryotic chromosomes, consist of tandem arrays of short
DNA repeats and a large set of specialized proteins. A recent analysis has identified …

Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and
make curing HIV-1 infections a major challenge. Most of the proviral DNA resides in CD4 + …

Template-dependent polynucleotide synthesis is catalyzed by enzymes whose core
component includes a ubiquitous αβ palm subdomain comprising A, B and C sequence motifs …

Transcription poses a threat to genomic stability through the formation of R-loops that can
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …

" It will require a courageous grasp of the politics and economics, as well as the cultural
propaganda, of heterosexuality to carry us beyond individual cases or diversified group …

Long noncoding telomeric repeat–containing RNA (TERRA) has been implicated in telomere
maintenance in a telomerase-dependent and a telomerase-independent manner during …

The duplication of the eukaryotic genome is an intricate process that has to be tightly safe‐guarded.
One of the most frequently occurring errors during DNA synthesis is the mis‐…

Vertebrate telomeres are transcribed into telomeric repeat-containing RNA (TERRA) that
associates with telomeres and may be important for telomere function. Here, we demonstrate …

Although telomeres are heterochromatic, they are transcribed into noncoding telomeric
repeat–containing RNA (TERRA). Here we show that RNA-DNA hybrids form at telomeres and …