Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system

…, MM Koletar, D Ringuette, R Gad, M Jeffrey… - Biomedical Optics …, 2016 - opg.optica.org
We report on a miniature label-free imaging system for monitoring brain blood flow and
blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams, …

Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats

AY Taha, MA Jeffrey, NMY Taha, S Bala… - Epilepsy & Behavior, 2010 - Elsevier
OBJECTIVE: Docosahexaenoic acid (DHA), an omega-3 fatty acid, has been reported to raise
seizure thresholds. The purpose of the present study was to test the acute anticonvulsant …

Methodology matters: Designing a pilot study guided by indigenous epistemologies

SA Juutilainen, M Jeffrey, S Stewart - Human Biology, 2020 - BioOne
Indigenous individuals and communities have experienced historic and ongoing negative
interactions with Western health care and biomedical research. To rebuild trust and mitigate …

Framework for evaluating potential causes of health risk factors using average treatment effect and uplift modelling

…, A Nakashook-Zettler, V Costanzo-Alvarez, M Jeffrey… - Algorithms, 2023 - mdpi.com
Acute myeloid leukemia (AML) is a type of blood cancer that affects both adults and children.
Benzene exposure has been reported to increase the risk of developing AML in children. …

Comparative study of five antiepileptic drugs on a translational cognitive measure in the rat: relationship to antiepileptic property

…, N Breysse, E Undzys, DR Derksen, M Jeffrey… - …, 2010 - Springer
Rationale Antiepileptic drugs (AEDs) have been available for many years; yet, new members
of this class continue to be identified and developed due to the limitations of existing drugs, …

A reliable method for intracranial electrode implantation and chronic electrical stimulation in the mouse brain

M Jeffrey, M Lang, J Gane, C Wu, WMI Burnham… - BMC neuroscience, 2013 - Springer
Background Electrical stimulation of brain structures has been widely used in rodent models
for kindling or modeling deep brain stimulation used clinically. This requires surgical …

[HTML][HTML] Traumatic spinal cord injuries among Aboriginal and non-Aboriginal populations of Saskatchewan: a prospective outcomes study

…, S Humphreys, C Rivers, M Jeffrey… - Canadian journal of …, 2020 - ncbi.nlm.nih.gov
Background People of Aboriginal (Indigenous) ancestry are more likely to experience traumatic
spinal cord injury (TSCI) than other Canadians; however, outcome studies are limited. …

Continuous multi-modality brain imaging reveals modified neurovascular seizure response after intervention

D Ringuette, MA Jeffrey, S Dufour… - Biomedical Optics …, 2017 - opg.optica.org
We developed a multi-modal brain imaging system to investigate the relationship between
blood flow, blood oxygenation/volume, intracellular calcium and electrographic activity during …

Multi-modal in vivo imaging of brain blood oxygenation, blood flow and neural calcium dynamics during acute seizures

D Ringuette, MA Jeffrey, PL Carlen… - … ; Neural Imaging and …, 2016 - spiedigitallibrary.org
Dysfunction of the vascular endothelium has been implicated in the development of epilepsy.
To better understand the relation between vascular function and seizure and provide a …

[BOOK][B] Progesterone and its metabolites: anticonvulsant and behavioral studies

MA Jeffrey - 2014 - search.proquest.com
Progesterone is a well-known anticonvulsant neurosteroid. Progesterone's inhibitory effects
in the brain have long been attributed to its secondary metabolite, 3-α, 5-α-…