Recapitulation of embryonic pancreatic development has enabled development of methods
for in vitro islet cell differentiation using human pluripotent stem cells (hPSCs), which have …

The year 2022 has been notable for game-changing early progress in clinical trials with
stem cell islets; durable and promising 20-year data with long-term outcomes in clinical islet …

Over the last century, diabetes has been treated with subcutaneous insulin, a discovery that
enabled patients to forego death from hyperglycemia. Despite novel insulin formulations, …

Purpose Incidence of super obesity (SO; BMI ≥ 50 kg/m 2 ) is growing rapidly and confers
worse metabolic complications than non-SO (BMI 30–50 kg/m 2 ). We aim to characterize …

… Verhoeff, Kevin a ; Marfil-Garza, Braulio A. a,b,c ; Shapiro, AM James d … Reproduced
with permission from Verhoeff et al. [12] . … Verhoeff K, Henschke SJ, Marfil-Garza BA, et al …

Background Acute care surgery (ACS) and emergency general surgery (EGS) services must
provide timely care and intervention for patients who have some of the most challenging …

Background Islet transplantation offers an effective treatment for selected people with type 1
diabetes and intractable hypoglycaemia. Long-term experience, however, remains limited. …

Background Induced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative
medicine as a renewable source for islets, dopaminergic neurons, retinal cells, and …

Introduction Increasing evidence suggests surgical patients are at risk for developing new,
persistent opioid use (NPOU) following surgery. This risk may be heightened for patients …

Because the heart and lungs are confined within the thoracic cavity, understanding their
interactions is integral for studying each system. Such interactions include changes in external …