Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates
such as those associated with RNA processing, but the rules that dictate their assembly, …

Background The hemoglobin threshold at which postoperative red-cell transfusion is
warranted is controversial. We conducted a randomized trial to determine whether a higher …

Prion-like propagation of tau aggregation might underlie the stereotyped progression of
neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in …

Intracellular bodies such as nucleoli, Cajal bodies and various signalling assemblies represent
membraneless organelles, or condensates, that form via liquid–liquid phase separation (…

Tau protein can transfer between neurons transneuronally and trans-synaptically, which is
thought to explain the progressive spread of tauopathy observed in the brain of patients with …

Phase transitions involving biomolecular liquids are a fundamental mechanism underlying
intracellular organization. In the cell nucleus, liquid-liquid phase separation of intrinsically …

Tauopathies are neurodegenerative disorders that affect distinct brain regions, progress at
different rates, and exhibit specific patterns of tau accumulation. The source of this diversity is …

All structures within living cells must form at the right time and place. This includes
condensates such as the nucleolus, Cajal bodies and stress granules, which form via liquid–liquid …

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

Background Observational studies have suggested that accelerated surgery is associated
with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed …