[HTML][HTML] Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia
AW Roberts, MS Davids, JM Pagel… - … England Journal of …, 2016 - Mass Medical Soc
Background New treatments have improved outcomes for patients with relapsed chronic
lymphocytic leukemia (CLL), but complete remissions remain uncommon. Venetoclax has a …
lymphocytic leukemia (CLL), but complete remissions remain uncommon. Venetoclax has a …
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
…, CH Park, CM Park, DC Phillips, AW Roberts… - Nature medicine, 2013 - nature.com
Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic
process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance …
process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance …
[HTML][HTML] Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory …
Purpose BCL2 overexpression is a hallmark of chronic lymphocytic leukemia (CLL). The novel
BH3 mimetic navitoclax (ABT-263) specifically inhibits BCL2 and related proteins BCL-x l …
BH3 mimetic navitoclax (ABT-263) specifically inhibits BCL2 and related proteins BCL-x l …
[PDF][PDF] The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
…, CL Scott, CL Day, S Cory, JM Adams, AW Roberts… - Cancer cell, 2006 - cell.com
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs
mimicking their natural antagonists, BH3-only proteins, might overcome chemoresistance…
mimicking their natural antagonists, BH3-only proteins, might overcome chemoresistance…
[HTML][HTML] Programmed anuclear cell death delimits platelet life span
…, S Ellis, PN Kelly, PG Ekert, D Metcalf, AW Roberts… - Cell, 2007 - cell.com
Platelets are anuclear cytoplasmic fragments essential for blood clotting and wound healing.
Despite much speculation, the factors determining their life span in the circulation are …
Despite much speculation, the factors determining their life span in the circulation are …
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
…, B Lockhart, F Colland, JA Hickman, AW Roberts… - Nature, 2016 - nature.com
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The
pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but …
pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but …
Characterizing interactions in fine magnetic particle systems using first order reversal curves
CR Pike, AP Roberts, KL Verosub - Journal of Applied Physics, 1999 - pubs.aip.org
We demonstrate a powerful and practical method of characterizing interactions in fine magnetic
particle systems utilizing a class of hysteresis curves known as first order reversal curves…
particle systems utilizing a class of hysteresis curves known as first order reversal curves…
First‐order reversal curve diagrams: A new tool for characterizing the magnetic properties of natural samples
AP Roberts, CR Pike… - Journal of Geophysical …, 2000 - Wiley Online Library
Paleomagnetic and environmental magnetic studies are commonly conducted on samples
containing mixtures of magnetic minerals and/or grain sizes. Major hysteresis loops are …
containing mixtures of magnetic minerals and/or grain sizes. Major hysteresis loops are …
SOCS3 negatively regulates IL-6 signaling in vivo
…, NA Nicola, D Metcalf, DJ Hilton, AW Roberts… - Nature …, 2003 - nature.com
Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological
negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is …
negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is …
The genomic landscape of hypodiploid acute lymphoblastic leukemia
…, M Minden, ID Lewis, LB To, P Marlton, AW Roberts… - Nature …, 2013 - nature.com
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …