Monovariate and multivariate analyses of use of routine bone scanning, computed tomography, magnetic resonance imaging and positron emission tomography in patients with stage I and II breast cancer
| Variable | Monovariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95%CI) | p value | OR (95% CI) | p value | |
| Age group, yr | ||||
| ≥ 70 | Ref | Ref | ||
| 60–69 | 1.240 (1.095–1.405) | 0.001 | 1.206 (1.029–1.412) | 0.020 |
| 50–59 | 1.346 (1.189–1.524) | < 0.001 | 1.267 (1.081–1.485) | 0.004 |
| 40–49 | 1.657 (1.445–1.901) | < 0.001 | 1.379 (1.154–1.648) | < 0.001 |
| < 40 | 2.859 (2.347–3.482) | < 0.001 | 1.551 (1.202–2.002) | 0.001 |
| CCI score | ||||
| 0 | Ref | Ref | ||
| 1 | 0.922 (0.807–1.053) | 0.232 | 0.891 (0.752–1.055) | 0.18 |
| ≥ 2 | 0.964 (0.775–1.199) | 0.742 | 0.807 (0.609–1.070) | 0.14 |
| Year of diagnosis | ||||
| 2011 | Ref | Ref | ||
| 2012 | 0.939 (0.817–1.080) | 0.378 | 0.886 (0.743–1.058) | 0.18 |
| 2013 | 0.846 (0.736–0.973) | 0.019 | 0.821 (0.687–0.980) | 0.029 |
| 2014 | 1.015 (0.887–1.161) | 0.831 | 1.011 (0.852–1.199) | 0.90 |
| 2015 | 0.836 (0.730–0.959) | 0.010 | 0.729 (0.612–0.868) | < 0.001 |
| Setting of diagnosis | ||||
| Urban | Ref | Ref | ||
| Rural | 1.792 (1.634–1.964) | < 0.001 | 2.107 (1.871–2.372) | < 0.001 |
| Surgery | ||||
| Mastectomy | Ref | Ref | ||
| BCS | 0.517 (0.474–0.565) | < 0.001 | 0.687 (0.614–0.768) | < 0.001 |
| Stage | ||||
| 0 (DCIS) | NA | NA | ||
| I | Ref | Ref | ||
| II | 5.508 (4.988–6.083) | < 0.001 | 2.254 (1.963–2.588) | < 0.001 |
| Lymph node status | ||||
| Negative | Ref | Ref | ||
| Positive | 9.931 (8.872–11.115 | < 0.001 | 4.763 (4.094–5.541) | < 0.001 |
| Grade | ||||
| I | Ref | Ref | ||
| 2 | 1.713 (1.496–1.961 | < 0.001 | 1.343 (1.141–1.581) | < 0.001 |
| 3 | 2.207 (1.929–2.526 | < 0.001 | 1.569 (1.308–1.883) | < 0.001 |
| LVI | ||||
| Absent | Ref | Ref | ||
| Present | 3.145 (2.843–3.478 | < 0.001 | 1.035 (0.905–1.183) | 0.62 |
| HER2 status | ||||
| Negative | Ref | Ref | ||
| Positive | 1.644 (1.444–1.873 | < 0.001 | 1.248 (1.051–1.483) | 0.012 |
| TNBC | ||||
| No | Ref | Ref | ||
| Yes | 1.250 (1.066–1.467 | 0.006 | 1.110 (0.903–1.364) | 0.32 |
BCS = breast-conserving surgery; CCI = Charlson Comorbidity Index; CI = confidence interval; DCIS = ductal carcinoma in situ; HER2 = human epidermal growth factor receptor 2; LVI = lymphovascular invasion; NA = not applicable; OR = odds ratio; Ref = reference category; TNBC = triple-negative breast cancer.