PT  - JOURNAL ARTICLE
AU  - Denis Bouchard
AU  - Bertrand Marcheix
AU  - Sfoug Al-Shamary
AU  - Frédéric Vanden Eynden
AU  - Philippe Demers
AU  - Danielle Robitaille
AU  - Michel Pellerin
AU  - Louis P. Perrault
AU  - Michel Carrier
TI  - Preoperative autologous blood donation reduces the need for allogeneic blood products: a prospective randomized study
DP  - 2008 Dec 01
TA  - Canadian Journal of Surgery
PG  - 422--427
VI  - 51
IP  - 6
4099  - http://canjsurg.ca/content/51/6/422.short
4100  - http://canjsurg.ca/content/51/6/422.full
SO  - CAN J SURG2008 Dec 01; 51
AB  - Objective: We sought to assess the efficacy of preoperative autologous blood donation in reducing patient exposure to allogeneic blood products following elective cardiac surgery.Methods: We included 48 patients in a prospective study and randomly assigned them into the control or treatment group. We excluded patients with aortic stenosis, main trunk stenosis and unstable angina. Group A (n = 23; coronary disease n = 21 and valvular disease n = 2) was the control group, and group B (n = 25; coronary disease n = 21, valvular disease n = 4) received preoperative autologous blood donation. All patients had cardiopulmonary bypass surgery, and we processed mediastinal blood with a cell-saver device before reinfusion. All patients received aprotinin, and we reinfused blood shed from the mediastinum postoperatively.Results: No major peri- or postoperative complications occurred. We interrupted preoperative blood donation in 2 patients (8%) because of worsened angina pectoris. The mean time between the first blood donation and surgery was 22.5 (standard deviation [SD] 9.4, range 12–50) days. In group A, 9 patients (39.1%) were exposed to allogeneic blood products. In group B, 11 patients (47.8%) were exposed to blood products (p = 0.73), and 4 (16%) were exposed to allogeneic blood products (p = 0.036).Conclusion: Preoperative blood donation was completed in 92% of the targeted low-risk population. The procedure significantly reduced exposure to perioperative allogeneic blood products.